Small nucleolar RNA SNORD73

In molecular biology, snoRNA U73 (also known as SNORD73) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

Small nucleolar RNA SNORD73
Predicted secondary structure and sequence conservation of SNORD73
Identifiers
Symbol	SNORD73
Alt. Symbols	U73
Rfam	RF00071
Other data
RNA type	Gene; snRNA; snoRNA; CD-box
Domain(s)	Eukaryota
GO	GO:0006396 GO:0005730
SO	SO:0000593
PDB structures	PDBe

snoRNA U73 is a member of the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.^[1]

U73 is encoded within the introns of ribosomal protein S3a and contains a 12 nucleotide region of complementarity to a conserved sequence in 28S ribosomal RNA (rRNA).^[2] U73 has been demonstrated to function as a 2'-O-ribose methylation guide RNA for pre-28S rRNA.^[3]