SMTN

Smoothelin is a protein that in humans is encoded by the SMTN gene.^[5][6][7]

SMTN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D87
Identifiers
Aliases	SMTN, smoothelin
External IDs	OMIM: 602127; MGI: 1354727; HomoloGene: 8482; GeneCards: SMTN; OMA:SMTN - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q12.2 Start 31,064,105 bp[1] End 31,104,757 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A1 Start 3,467,523 bp[2] End 3,490,612 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastric mucosa popliteal artery tibial arteries muscle layer of sigmoid colon body of uterus apex of heart left uterine tube Descending thoracic aorta ascending aorta right coronary artery Top expressed in tunica media of zone of aorta ascending aorta uterus lip aortic valve temporal muscle digastric muscle sternocleidomastoid muscle triceps brachii muscle muscle of thigh More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding structural constituent of muscle Cellular component cytoplasm cytoskeleton actin cytoskeleton microtubule organizing center filamentous actin nucleoplasm Biological process smooth muscle contraction muscle organ development actin cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6525 29856 Ensembl ENSG00000183963 ENSMUSG00000020439 UniProt P53814 Q921U8 RefSeq (mRNA) NM_001207017 NM_001207018 NM_006932 NM_134269 NM_134270 NM_001159284 NM_001284427 NM_001284428 NM_001284429 NM_013870 RefSeq (protein) NP_001193946 NP_001193947 NP_008863 NP_599031 NP_599032 NP_001369567 NP_001369568 NP_001369569 NP_001369570 NP_001369571 NP_001369572 NP_001369573 NP_001369574 NP_001369575 NP_001369576 NP_001369577 NP_001152756 NP_001271356 NP_001271357 NP_001271358 NP_038898 Location (UCSC) Chr 22: 31.06 – 31.1 Mb Chr 11: 3.47 – 3.49 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a structural protein that is found exclusively in contractile smooth muscle cells. It associates with stress fibers and constitutes part of the cytoskeleton. This gene is localized to chromosome 22q12.3, distal to the TUPLE1 locus and outside the DiGeorge syndrome deletion. Alternative splicing of this gene results in three transcript variants.^[7]