Solangepras

Solangepras (INNTooltip International Nonproprietary Name; developmental code name CVN-424), or solengepras (USANTooltip United States Adopted Name), is an inverse agonist of the orphan G protein-coupled receptor 6 (GPR6) which is under development for the treatment of Parkinson's disease.^[1][2][3][4] It is a small molecule and is taken by mouth.^[1][4] Solangepras produces hyperlocomotion and reverses haloperidol-induced catalepsy in rodents.^[4] It is being developed by Cerevance.^[1][2] As of October 2024, solangepras is in phase 3 clinical trials.^[1][2]

Solangepras

Clinical data
Other names	Solengepras; CVN-424; CVN424
Routes of administration	Oral[1]
Drug class	GPR6 inverse agonist
Identifiers
IUPAC name 1-[2-[4-(2,4-difluorophenoxy)piperidin-1-yl]-3-[[(3R)-oxolan-3-yl]amino]-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl]ethanone
CAS Number	2254706-21-1
PubChem CID	137359492
DrugBank	DB18958
ChemSpider	114869317
UNII	XO01711URG
KEGG	D12980
ChEMBL	ChEMBL4778540
Chemical and physical data
Formula	C24H29F2N5O3
Molar mass	473.525 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(=O)N1CCC2=C(C1)N=C(C(=N2)N3CCC(CC3)OC4=C(C=C(C=C4)F)F)N[C@@H]5CCOC5
InChI InChI=1S/C24H29F2N5O3/c1-15(32)31-10-6-20-21(13-31)28-23(27-17-7-11-33-14-17)24(29-20)30-8-4-18(5-9-30)34-22-3-2-16(25)12-19(22)26/h2-3,12,17-18H,4-11,13-14H2,1H3,(H,27,28)/t17-/m1/s1 Key:HSWVJQBEXRKOBZ-QGZVFWFLSA-N