Somatostatin receptor

Somatostatin receptors are receptors for the ligand somatostatin, a small neuropeptide associated with neural signaling, particularly in the post-synaptic response to NMDA receptor co-stimulation/activation. Somatostatin is encoded by a CRE and is very susceptible to gene promoter region activation by transcription factor CREB.^[1]

Image showing somatostatin biochemical pathway complete with target cell somatostatin receptor

somatostatin receptor 1
Identifiers
Symbol	SSTR1
NCBI gene	6751
HGNC	11330
OMIM	182451
RefSeq	NM_001049
UniProt	P30872
Other data
Locus	Chr. 14 q13
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somatostatin receptor 2
Identifiers
Symbol	SSTR2
NCBI gene	6752
HGNC	11331
OMIM	182452
RefSeq	NM_001050
UniProt	P30874
Other data
Locus	Chr. 17 q24
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somatostatin receptor 3
Identifiers
Symbol	SSTR3
NCBI gene	6753
HGNC	11332
OMIM	182453
RefSeq	NM_001051
UniProt	P32745
Other data
Locus	Chr. 22 q13.1
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somatostatin receptor 4
Identifiers
Symbol	SSTR4
NCBI gene	6754
HGNC	11333
OMIM	182454
RefSeq	NM_001052
UniProt	P31391
Other data
Locus	Chr. 20 p11.2
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somatostatin receptor 5
Identifiers
Symbol	SSTR5
NCBI gene	6755
HGNC	11334
OMIM	182455
RefSeq	NM_001053
UniProt	P35346
Other data
Locus	Chr. 16 p13.3
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There are five known somatostatin receptors:^[2]

• SST₁ (SSTR1)
• SST₂ (SSTR2)
• SST₃ (SSTR3)
• SST₄ (SSTR4)
• SST₅ (SSTR5)

All are G protein-coupled seven transmembrane receptors.