Sorbitol-6-phosphate 2-dehydrogenase

In enzymology, sorbitol-6-phosphate dehydrogenase (EC 1.1.1.140) is an enzyme that catalyzes the chemical reaction

D-sorbitol 6-phosphate

+ NAD⁺

 

 

 

H⁺

 

H⁺

 

fructose 6-phosphate

+ NADH

 

sorbitol-6-phosphate 2-dehydrogenase
Identifiers
EC no.	1.1.1.140
CAS no.	37250-69-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The two substrates of this enzyme are D-sorbitol 6-phosphate and oxidised nicotinamide adenine dinucleotide (NAD⁺). Its products are fructose 6-phosphate (shown in its open-chain form), reduced NADH, and a proton.^[1][2][3]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is D-sorbitol-6-phosphate:NAD⁺ 2-oxidoreductase. Other names in common use include ketosephosphate reductase, ketosephosphate reductase, D-sorbitol 6-phosphate dehydrogenase, D-sorbitol-6-phosphate dehydrogenase, sorbitol-6-P-dehydrogenase, and D-glucitol-6-phosphate dehydrogenase. This enzyme participates in fructose and mannose metabolism.