Spiradoline

Spiradoline
Clinical data
Routes of; administration	N/A
ATC code	none;
Identifiers
	IUPAC name 2-(3,4-Dichlorophenyl)-N-methyl-N-[(5R,7S,8S)-7-pyrrolidin-1-yl-1-oxaspiro[4.5]decan-8-yl] acetamide;
CAS Number	87151-85-7 ;
PubChem CID	55652;
IUPHAR/BPS	1653;
ChemSpider	50257 ;
UNII	N18ZH0M4NP;
ChEMBL	ChEMBL118865 ;
CompTox Dashboard (EPA)	DTXSID1048679 ;
Chemical and physical data
Formula	C22H30Cl2N2O2
Molar mass	425.39 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN([C@H]1CC[C@@]2(CCCO2)C[C@@H]1N3CCCC3)C(=O)CC4=CC(=C(C=C4)Cl)Cl;
	InChI InChI=1S/C22H30Cl2N2O2/c1-25(21(27)14-16-5-6-17(23)18(24)13-16)19-7-9-22(8-4-12-28-22)15-20(19)26-10-2-3-11-26/h5-6,13,19-20H,2-4,7-12,14-15H2,1H3/t19-,20-,22-/m0/s1 ; Key:NYKCGQQJNVPOLU-ONTIZHBOSA-N ;
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Spiradoline (U-62066) is a drug which acts as a highly selective κ-opioid agonist.^[1] It has analgesic,^[2] diuretic,^[3] and antitussive effects,^[4] and produces subjective effects in animals similar to those of ketazocine and alazocine.^[5] The main effect in humans is sedation, along with analgesic and diuretic effects, but significant side effects such as dysphoria and hallucinations have stopped it from being used clinically.^[6]

Quick Facts Clinical data, Routes ofadministration ...

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Spiradoline

See also

References

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