SprX small RNA

In molecular biology the small pathogenicity island RNA X (alias RsaOR) gene is a bacterial non-coding RNA. It was discovered in a large-scale analysis of Staphylococcus aureus.^[1] SprX was shown to influence antibiotic resistance of the bacteria to Vancomycin and Teicoplanin glycopeptides, which are used to treat MRSA infections.^[2] In this study the authors identified a SprX target, stage V sporulation protein G (Spo VG). By reducing Spo VG expression levels, SprX affects S. aureus resistance to the glycopeptide antibiotics. Further work demonstrated its involvement in the regulation of pathogenicity factors.^[3]

SprX sRNA
Predicted secondary structure and sequence conservation of SprX small RNA
Identifiers
Rfam	RF02672
Other data
Domain(s)	Bacteria
GO	GO:0040033
SO	SO:0000370
PDB structures	PDBe

See also

• SprD