SraL RNA

The SraL RNA ('sra' for small RNA), also known as RyjA, is a small non-coding RNA discovered in E. coli,^[1][2] and later in Salmonella Tiphimurium.^[3][4] This ncRNA was found to be expressed only in stationary phase.^[1] It may possibly play a role in Salmonella virulence.^[3] The major stationary phase regulator RpoS is transcriptionally regulating SraL and directly binds to the sraL gene promoter. SraL down-regulates the expression of the ribosome-associated chaperone Trigger Factor (TF), which is involved in the folding of the newly synthesised cystolic proteins.^[5]