Top Qs
Timeline
Chat
Perspective

Src inhibitor

From Wikipedia, the free encyclopedia

Src inhibitor
Remove ads

Src inhibitor is a class of inhibitors[jargon] that targets the Src kinase family of tyrosine kinase, which is transcribed by the Src proto-oncogene (short for "sarcoma gene") that potentially induce malignant transformations of certain cells. Because of the crucial position of the Src kinase in cells, Src inhibitors are potential antineoplastic agents for e.g. pancreatic cancer, breast cancer and stomach cancer[1]

Thumb
Chemical structure of tirbanibulin
Remove ads

Examples

  • Tirbanibulin is an oral src inhibitor and the first clinical inhibitor with GI50 of 9–60 nM in cancer cell lines.[2]
  • Bosutinib has been developed for the treatment of chronic myelogenous leukemia by Pfizer.
  • Saracatinib, the first Src inhibitor to show inhibition of the Src pathway in human tumor tissue, has anti-tumor activity alone or in combination with chemotherapeutic agents.[3]
Thumb
Chemical structure of PP1
Remove ads

References

Loading related searches...

Wikiwand - on

Seamless Wikipedia browsing. On steroids.

Remove ads