Stanley Fields (biologist)

Stanley Fields is an American biologist best known for developing the yeast two hybrid method for identifying protein–protein interactions.^[1] He is currently a professor of Genome Sciences at the University of Washington and Howard Hughes Medical Institute Investigator,^[2][3] and previously served as chair of the Department of Genome Sciences.^[4]

Stan Fields
Born	Stanley Fields
Alma mater	University of Cambridge
Known for	Two-hybrid screening
Scientific career
Institutions	Laboratory of Molecular Biology Howard Hughes Medical Institute University of Washington
Thesis	Sequence analysis of influenza virus RNA (1981)
Website	depts.washington.edu/sfields www.gs.washington.edu/faculty/fields.htm www.hhmi.org/research/investigators/fields.html

Education

Fields was educated at the University of Cambridge where he was awarded a Doctor of Philosophy in 1981 for research carried out in the Laboratory of Molecular Biology with Greg Winter and George Brownlee.^[5][6]

Research

Fields developed the yeast two-hybrid system in 1989,^[1] which has been widely used by Fields^{[7][8][9][10]} and others to identify protein-protein interactions in various organisms and biological contexts.

Along with Matt Kaeberlein and Brian Kennedy, in later work Fields has carried out genome-wide screens for aging genes in yeast. Kaeberlein and co-workers have questioned the hypothesis that lifespan extension from caloric restriction is mediated by Sirtuins.^[11] Instead Kaeberlein, Fields, and Kennedy have proposed that caloric restriction increases lifespan by decreasing the activity of the Target of Rapamycin (TOR) kinase.^[12]

Honors and awards

• 2003 Jacob Heskel Gabbay Award in Biotechnology and Medicine (jointly with Roger Brent) ^[13]