Sterol regulatory element-binding protein 2

Sterol regulatory element-binding protein 2 (SREBP-2) also known as sterol regulatory element binding transcription factor 2 (SREBF2) is a protein that in humans is encoded by the SREBF2 gene.^[5]

SREBF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UKL
Identifiers
Aliases	SREBF2, SREBP-2, SREBP2, bHLHd2, sterol regulatory element binding transcription factor 2
External IDs	OMIM: 600481; MGI: 107585; HomoloGene: 20966; GeneCards: SREBF2; OMA:SREBF2 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.2 Start 41,833,079 bp[1] End 41,907,307 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E1 Start 82,031,382 bp[2] End 82,089,580 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone right hemisphere of cerebellum right adrenal cortex left adrenal cortex right frontal lobe tibial nerve prefrontal cortex cingulate gyrus mucosa of transverse colon Top expressed in ventricular zone lip superior frontal gyrus primary visual cortex dentate gyrus of hippocampal formation granule cell neural tube yolk sac granulocyte neural layer of retina tail of embryo More reference expression data BioGPS n/a
Gene ontology Molecular function C-8 sterol isomerase activity DNA binding protein dimerization activity DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific E-box binding protein C-terminus binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm integral component of membrane cytosol SREBP-SCAP-Insig complex Golgi apparatus endoplasmic reticulum membrane membrane Golgi membrane endoplasmic reticulum ER to Golgi transport vesicle membrane cytoplasmic vesicle nucleus nucleoplasm mitochondrion intracellular membrane-bounded organelle Biological process steroid metabolic process regulation of transcription, DNA-templated positive regulation of protein targeting to mitochondrion lipid metabolism positive regulation of cholesterol storage cellular response to laminar fluid shear stress cellular response to starvation cholesterol metabolic process negative regulation of transcription by RNA polymerase II transcription, DNA-templated regulation of autophagy of mitochondrion negative regulation of cholesterol efflux positive regulation of transcription by RNA polymerase II regulation of cholesterol biosynthetic process cellular response to low-density lipoprotein particle stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6721 20788 Ensembl ENSG00000198911 ENSMUSG00000022463 UniProt Q12772 Q3U1N2 RefSeq (mRNA) NM_004599 NM_033218 RefSeq (protein) NP_004590 NP_150087 Location (UCSC) Chr 22: 41.83 – 41.91 Mb Chr 15: 82.03 – 82.09 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix leucine zipper (bHLH-Zip) domain.^[6] Various single nucleotide polymorphisms (SNPs) of the SREBF2 have been identified and some of them are found to be associated with higher risk of knee osteoarthritis. ^[7]

Interactions

SREBF2 has been shown to interact with INSIG1^[8][9] and the CREB-binding protein.^[10]

See also

• Sterol regulatory element-binding protein