Stizolobate synthase

In enzymology, a stizolobate synthase (EC 1.13.11.29) is an enzyme that catalyzes the chemical reaction

3,4-dihydroxy-L-phenylalanine + O₂ ${\displaystyle \rightleftharpoons }$ 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde

stizolobate synthase
Identifiers
EC no.	1.13.11.29
CAS no.	65979-39-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are 3,4-dihydroxy-L-phenylalanine and O₂, whereas its product is 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O₂. The systematic name of this enzyme class is 3,4-dihydroxy-L-phenylalanine:oxygen 4,5-oxidoreductase (recyclizing). This enzyme participates in tyrosine metabolism. It employs one cofactor, zinc.