Succinate-semialdehyde dehydrogenase (acylating)

Succinate-semialdehyde dehydrogenase (acylating) (EC 1.2.1.76, succinyl-coA reductase, coenzyme-A-dependent succinate-semialdehyde dehydrogenase) is an enzyme with systematic name succinate semialdehyde:NADP⁺ oxidoreductase (CoA-acylating).^[1][2][3] This enzyme catalyses the following chemical reaction

succinate semialdehyde + CoA + NADP⁺ ${\displaystyle \rightleftharpoons }$ succinyl-CoA + NADPH + H⁺

Succinate-semialdehyde dehydrogenase (acylating)
Identifiers
EC no.	1.2.1.76
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
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Catalyses the NADPH-dependent reduction of succinyl-CoA to succinate semialdehyde.