Top Qs
Timeline
Chat
Perspective

Sulbactam

Chemical compound From Wikipedia, the free encyclopedia

Sulbactam
Remove ads

Sulbactam is a β-lactamase inhibitor. This drug is given in combination with β-lactam antibiotics to inhibit β-lactamase, an enzyme produced by bacteria that destroys the antibiotics.[1]

Quick Facts Clinical data, AHFS/Drugs.com ...

It was patented in 1977 and approved for medical use in 1986.[2]

Remove ads

Medical uses

The combination ampicillin/sulbactam (Unasyn) is available in the United States.[3]

The combination cefoperazone/sulbactam (Sulperazon) is available in many countries but not in the United States.[4]

The co-packaged combination sulbactam/durlobactam was approved for medical use in the United States in May 2023.[5]

Mechanism

Sulbactam is primarily used as a suicide inhibitor of β-lactamase, shielding more potent beta-lactams such as ampicillin.[6] Sulbactam itself contains a beta-lactam ring, and has weak antibacterial activity by inhibiting penicillin binding proteins (PBP) 1 and 3, but not 2.[7]

References

Further reading

Loading related searches...

Wikiwand - on

Seamless Wikipedia browsing. On steroids.

Remove ads