Sulfadoxine

Sulfadoxine
Clinical data
AHFS/Drugs.com	International Drug Names
ATCvet code	QJ01EQ13 (WHO) ;
Identifiers
	IUPAC name 4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide;
CAS Number	2447-57-6 ;
PubChem CID	17134;
DrugBank	DB01299 ;
ChemSpider	16218 ;
UNII	88463U4SM5;
KEGG	D00580 ;
ChEMBL	ChEMBL1539 ;
NIAID ChemDB	007816;
CompTox Dashboard (EPA)	DTXSID6023608 ;
ECHA InfoCard	100.017.732
Chemical and physical data
Formula	C12H14N4O4S
Molar mass	310.33 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	190 to 194 °C (374 to 381 °F)
	SMILES COC1=C(N=CN=C1OC)NS(=O)(=O)C2=CC=C(C=C2)N;
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Sulfadoxine (also spelled sulphadoxine) is an ultra-long-lasting sulfonamide used in combination with pyrimethamine to treat malaria.^[1]

Quick Facts Clinical data, AHFS/Drugs.com ...

It is also used to prevent malaria^[2] but due to high levels of sulphadoxine-pyrimethamine resistance, this use has become less common.^[3]

It is also used, usually in combination with other drugs, to treat or prevent various infections in livestock.^{[citation needed]}

Mechanism of action