SYNPO

Synaptopodin is a protein that in humans is encoded by the SYNPO gene.^[5][6][7]

SYNPO
Identifiers
Aliases	SYNPO, synaptopodin
External IDs	OMIM: 608155; MGI: 1099446; HomoloGene: 5274; GeneCards: SYNPO; OMA:SYNPO - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q33.1 Start 150,601,080 bp[1] End 150,659,207 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 D3- E1 Start 60,727,045 bp[2] End 60,793,214 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh apex of heart Descending thoracic aorta gastrocnemius muscle Skeletal muscle tissue of rectus abdominis ascending aorta right coronary artery right auricle of heart tendon of biceps brachii left ventricle Top expressed in ascending aorta aortic valve muscle of thigh external carotid artery tunica media of zone of aorta lumbar spinal ganglion dentate gyrus of hippocampal formation granule cell superior frontal gyrus cumulus cell ankle joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding actin binding Cellular component cytoplasm perikaryon cell junction postsynaptic membrane dendritic spine plasma membrane cell projection synapse cytoskeleton membrane postsynaptic density bicellular tight junction Z discdkac nucleus actin cytoskeleton stress fiber spine apparatus Schaffer collateral - CA1 synapse glutamatergic synapse Biological process positive regulation of actin filament bundle assembly regulation of stress fiber assembly spine apparatus assembly visual learning regulation of long-term neuronal synaptic plasticity modification of dendritic spine postsynaptic modulation of chemical synaptic transmission positive regulation of postsynaptic cytosolic calcium concentration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11346 104027 Ensembl ENSG00000171992 ENSMUSG00000043079 UniProt Q8N3V7 Q8CC35 RefSeq (mRNA) NM_001109974 NM_001166208 NM_001166209 NM_007286 NM_001109975 NM_177340 RefSeq (protein) NP_001103444 NP_001159680 NP_001159681 NP_009217 NP_001103445 NP_796314 Location (UCSC) Chr 5: 150.6 – 150.66 Mb Chr 18: 60.73 – 60.79 Mb PubMed search [3] [4]
Wikidata
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Function

Synaptopodin is an actin-associated protein that may play a role in actin-based cell shape and motility. The name synaptopodin derives from the protein's associations with postsynaptic densities and dendritic spines and with renal podocytes (Mundel et al., 1997).[supplied by OMIM]^[7]

Interactions

SYNPO has been shown to interact with MAGI1.^[8]