Transgelin

Transgelin is a protein that in humans is encoded by the TAGLN gene.^[5][6][7]

TAGLN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UJO
Identifiers
Aliases	TAGLN, SM22, SMCC, TAGLN1, WS3-10, transgelin, SM22-alpha
External IDs	OMIM: 600818; MGI: 106012; HomoloGene: 2398; GeneCards: TAGLN; OMA:TAGLN - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.3 Start 117,199,370 bp[1] End 117,207,464 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 A5.2|9 25.36 cM Start 45,840,917 bp[2] End 45,847,356 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in saphenous vein popliteal artery tibial arteries right coronary artery ascending aorta Descending thoracic aorta left coronary artery tail of epididymis myometrium urethra Top expressed in tunica media of zone of aorta ascending aorta umbilical cord cervix aortic valve seminal vesicula left colon calvaria gallbladder tunica adventitia of aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding actin binding actin filament binding Cellular component cytoplasm Biological process muscle organ development epithelial cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6876 21345 Ensembl ENSG00000149591 ENSMUSG00000032085 UniProt Q01995 P37804 RefSeq (mRNA) NM_003186 NM_001001522 NM_011526 RefSeq (protein) NP_001001522 NP_003177 NP_035656 Location (UCSC) Chr 11: 117.2 – 117.21 Mb Chr 9: 45.84 – 45.85 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene.^[7]