ELOA

Elongin A is a protein that in humans is encoded by the ELOA gene.^[5][6][7]

ELOA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4HFX
Identifiers
Aliases	ELOA, EloA, SIII, SIII p110, TCEB3A, TCEB3, transcription elongation factor B subunit 3, elongin A
External IDs	OMIM: 600786; MGI: 1351315; HomoloGene: 37746; GeneCards: ELOA; OMA:ELOA - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.11 Start 23,743,448 bp[1] End 23,762,059 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D3 Start 135,730,679 bp[2] End 135,749,074 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell lower lobe of lung cardia glutes Skeletal muscle tissue of biceps brachii myocardium of left ventricle skin of arm Skeletal muscle tissue of rectus abdominis gingival epithelium thoracic diaphragm Top expressed in molar granulocyte plantaris muscle extensor digitorum longus muscle triceps brachii muscle ankle medial head of gastrocnemius muscle temporal muscle quadriceps femoris muscle muscle of thigh More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component nucleus nucleoplasm extracellular space elongin complex Biological process transcription elongation from RNA polymerase II promoter regulation of transcription, DNA-templated transcription by RNA polymerase II transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6924 27224 Ensembl ENSG00000011007 ENSMUSG00000028668 UniProt Q14241 Q8CB77 RefSeq (mRNA) NM_003198 NM_013736 RefSeq (protein) NP_003189 NP_038764 Location (UCSC) Chr 1: 23.74 – 23.76 Mb Chr 4: 135.73 – 135.75 Mb PubMed search [3] [4]
Wikidata
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Elongin A is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis and is capable of forming a stable complex with elongins B and C. The von Hippel–Lindau tumor suppressor protein binds to elongins B and C and thereby inhibits transcription elongation.^[7]