TCS-OX2-29

TCS-OX2-29 is an orexin antagonist. It was the first non-peptide antagonist developed that is selective for the orexin receptor subtype OX₂, with an IC₅₀ of 40nM and selectivity of around 250x for OX₂ over OX₁ receptors.^[1] Orexin antagonists are expected to be useful for the treatment of insomnia, with subtype-selective antagonists such as TCS-OX2-29 potentially offering more specificity of action compared to non-selective orexin antagonists like almorexant.^[2]

TCS-OX2-29

Identifiers
IUPAC name (2S)-1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3,3-dimethyl-2-(pyridin-4-ylmethylamino)butan-1-one
CAS Number	372523-75-6
PubChem CID	10408514
IUPHAR/BPS	4038
UNII	KH2US47J8R
CompTox Dashboard (EPA)	DTXSID801028419
Chemical and physical data
Formula	C23H31N3O3
Molar mass	397.519 g·mol−1
3D model (JSmol)	Interactive image
SMILES c3cnccc3CNC(C(C)(C)C)C(=O)N(Cc2cc1OC)CCc2cc1OC
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