Top Qs
Timeline
Chat
Perspective
TEL-JAK2
Fusion gene From Wikipedia, the free encyclopedia
Remove ads
TEL-JAK2 is a gene fusion resulting from a chromosomal translocation between chromosomes 9 and 12 observed in human leukemia.[1][2] The 5' moiety of TEL is fused to the 3' end of JAK2.
 | This article may be confusing or unclear to readers. (December 2022) |
The oligomerisation domain of the TEL protein (also called ETV6) becomes juxtaposed to the tyrosine kinase domain of JAK2, and as result the TEL-JAK2 displays constitutive kinase activity.
Remove ads
References
External links
Wikiwand - on
Seamless Wikipedia browsing. On steroids.
Remove ads