Thrombospondin-2

Thrombospondin-2 is a protein that in humans is encoded by the THBS2 gene.^[5][6]

THBS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1YO8, 2RHP
Identifiers
Aliases	THBS2, TSP2, thrombospondin 2
External IDs	OMIM: 188061; MGI: 98738; HomoloGene: 2438; GeneCards: THBS2; OMA:THBS2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q27 Start 169,215,780 bp[1] End 169,254,044 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A2|17 8.95 cM Start 14,885,762 bp[2] End 14,914,497 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pericardium right coronary artery stromal cell of endometrium saphenous vein tibia skin of hip hair follicle thoracic aorta ascending aorta Descending thoracic aorta Top expressed in calvaria stroma of bone marrow body of femur ankle dermis semi-lunar valve umbilical cord atrioventricular valve aortic valve ankle joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding protein binding heparin binding extracellular matrix structural constituent Cellular component extracellular matrix platelet alpha granule basement membrane extracellular region extracellular space collagen-containing extracellular matrix Biological process positive regulation of synapse assembly negative regulation of angiogenesis cell adhesion extracellular matrix organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7058 21826 Ensembl ENSG00000186340 ENSMUSG00000023885 UniProt P35442 Q03350 RefSeq (mRNA) NM_003247 NM_011581 RefSeq (protein) NP_003238 NP_001368868 NP_001368869 NP_001368870 NP_001368871 NP_035711 Location (UCSC) Chr 6: 169.22 – 169.25 Mb Chr 17: 14.89 – 14.91 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. The role of the protein in cancer is controversial, contrasting studies show positive and negative roles for cancer development. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration.^[6]

Interactions

THBS2 has been shown to interact with MMP2.^[7]