THIQ

This article is about the selective MC₄ agonist. For the heterocyclic amine, see Tetrahydroisoquinoline.

THIQ is a drug used in scientific research, which is the first non-peptide agonist developed that is selective for the melanocortin receptor subtype MC₄.^[1][2] In animal studies, THIQ stimulated sexual activity in rats,^[3] but with little effect on appetite or inflammation.^[4] This supports possible application of MC₄ selective agonists for the treatment of sexual dysfunction in humans,^[5] although THIQ itself has poor oral bioavailability and a short duration of action so improved analogues will need to be developed.^[6]

THIQ

Identifiers
IUPAC name N-[(3R)-1,2,3,4-tetrahydroisoquinolinium-3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl) -2-[4-cyclohexyl-4-(1H-1,2,4-triazol-1ylmethyl)piperidin-1-yl]-2-oxoethylamine
CAS Number	312637-48-2 Y
PubChem CID	9938402
IUPHAR/BPS	1338
ChemSpider	8114027
CompTox Dashboard (EPA)	DTXSID00953320
Chemical and physical data
Formula	C33H41ClN6O2
Molar mass	589.18 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1CCC(CC1)C2(CCN(CC2)C(=O)[C@@H](CC3=CC=C(C=C3)Cl)NC(=O)[C@H]4CC5=CC=CC=C5CN4)CN6C=NC=N6
InChI InChI=1S/C33H41ClN6O2/c34-28-12-10-24(11-13-28)18-30(38-31(41)29-19-25-6-4-5-7-26(25)20-36-29)32(42)39-16-14-33(15-17-39,21-40-23-35-22-37-40)27-8-2-1-3-9-27/h4-7,10-13,22-23,27,29-30,36H,1-3,8-9,14-21H2,(H,38,41)/t29-,30-/m1/s1 Key:HLCHESOMJVGDSJ-LOYHVIPDSA-N
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See also

• Bremelanotide
• Melanotan II
• PL-6983
• PF-00446687