T-cell lymphoma invasion and metastasis-inducing protein 1

Rho guanine nucleotide exchange factor TIAM1 is a protein that in humans is encoded by the TIAM1 gene.^[4][5][6]

TIAM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D8I, 3KZD, 3KZE, 4GVC, 4GVD, 4K2O, 4K2P, 4NXP, 4NXQ, 4NXR
Identifiers
Aliases	TIAM1, T-cell lymphoma invasion and metastasis-inducing protein 1, T-cell lymphoma invasion and metastasis 1
External IDs	OMIM: 600687; MGI: 103306; HomoloGene: 2443; GeneCards: TIAM1; OMA:TIAM1 - orthologs
Gene location (Mouse) Chr. Chromosome 16 (mouse)[1] Band 16 C3.3|16 51.5 cM Start 89,583,999 bp[1] End 89,940,657 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) n/a Top expressed in zygote primary oocyte secondary oocyte olfactory tubercle lobe of cerebellum medial geniculate nucleus lateral geniculate nucleus cerebellar vermis medial dorsal nucleus piriform cortex BioGPS More reference expression data
Gene ontology Molecular function microtubule binding kinase binding protein binding lipid binding guanyl-nucleotide exchange factor activity receptor tyrosine kinase binding Cellular component cytoplasm cytosol membrane cell-cell junction cell-cell contact zone extrinsic component of cytoplasmic side of plasma membrane plasma membrane dendritic spine axonal growth cone synapse main axon ruffle membrane cell junction soma somatodendritic compartment microtubule nucleus postsynaptic density glutamatergic synapse extrinsic component of postsynaptic density membrane Biological process protein localization to membrane apoptotic process regulation of insulin secretion involved in cellular response to glucose stimulus intracellular signal transduction activation of GTPase activity positive regulation of JUN kinase activity ephrin receptor signaling pathway cardiac muscle hypertrophy regulation of non-canonical Wnt signaling pathway positive regulation of axonogenesis neuron projection extension Wnt signaling pathway, planar cell polarity pathway regulation of dopaminergic neuron differentiation regulation of ERK1 and ERK2 cascade positive regulation of neuron projection development positive regulation of apoptotic process positive regulation of Schwann cell chemotaxis positive regulation of protein binding cell-matrix adhesion Rac protein signal transduction regulation of Rho protein signal transduction regulation of small GTPase mediated signal transduction cell migration positive regulation of dendritic spine morphogenesis signal transduction response to cocaine positive regulation of cell population proliferation positive regulation of cell migration NMDA selective glutamate receptor signaling pathway regulation of modification of postsynaptic actin cytoskeleton regulation of epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7074 21844 Ensembl ENSG00000156299 ENSMUSG00000002489 UniProt Q13009 Q60610 RefSeq (mRNA) NM_003253 NM_001145886 NM_001145887 NM_009384 RefSeq (protein) NP_003244 NP_001340613 NP_001340614 NP_001340615 NP_001340616 NP_001340617 NP_001340618 NP_001340619 NP_001340620 NP_001340621 NP_001340622 NP_001340623 n/a Location (UCSC) n/a Chr 16: 89.58 – 89.94 Mb PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Structure

TIAM1 is tightly associate with BAIAP2 as a subunit. It contains one DH (DBL-homology) domain, one PDZ domain, two PH domains and one Ras-binding RBD domain.

Function

TIAM1 modulates the activity of Rho GTP-binding proteins and connects extracellular signals to cytoskeletal activities. In addition, TIAM1 activates Rac1, CDC42, and to a lesser extent RhoA.

Clinical significance

TIAM1 is found in virtually all tumor cell lines examined including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas.

Interactions

T-cell lymphoma invasion and metastasis-inducing protein 1 has been shown to interact with ANK1,^[7] Myc,^[8] RAC1^[9][10] and PPP1R9B.^[11]

Tiam1 interacts also with para-cingulin, that plays a role in recruiting Tiam1 to junctions and thus activate Rac1 at epithelial junctions.^[12]