SEC62

Translocation protein SEC62 is a protein that in humans is encoded by the SEC62 gene.^[5][6][7]

SEC62
Identifiers
Aliases	SEC62, Dtrp1, HTP1, TLOC1, TP-1, SEC62 homolog, preprotein translocation factor
External IDs	OMIM: 602173; MGI: 1916526; HomoloGene: 2449; GeneCards: SEC62; OMA:SEC62 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q26.2 Start 169,966,635 bp[1] End 169,998,373 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 A3 Start 30,847,024 bp[2] End 30,875,412 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell superior vestibular nucleus pons parotid gland inferior ganglion of vagus nerve pars reticulata Brodmann area 23 cardia renal medulla pars compacta Top expressed in saccule otic placode facial motor nucleus seminal vesicula lobe of prostate lacrimal gland anterior horn of spinal cord epithelium of lens parotid gland supraoptic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor activity Cellular component integral component of membrane cytosol rough endoplasmic reticulum endoplasmic reticulum membrane membrane endoplasmic reticulum integral component of endoplasmic reticulum membrane Biological process protein transport posttranslational protein targeting to endoplasmic reticulum membrane cotranslational protein targeting to membrane signal transduction posttranslational protein targeting to membrane, translocation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7095 69276 Ensembl ENSG00000008952 ENSMUSG00000027706 UniProt Q99442 Q8BU14 RefSeq (mRNA) NM_003262 NM_027016 NM_001357528 RefSeq (protein) NP_003253 NP_081292 NP_001344457 Location (UCSC) Chr 3: 169.97 – 170 Mb Chr 3: 30.85 – 30.88 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER.^[7]