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TSPAN7

Protein-coding gene in humans From Wikipedia, the free encyclopedia

TSPAN7
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Tetraspanin-7 is a protein that in humans is encoded by the TSPAN7 gene.[5][6]

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The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. This gene is associated with X-linked mental retardation and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy.[6] More recently, it has been identified as a key immune system target in type 1 diabetes.[7]

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