Tropomodulin 3

Tropomodulin-3 is a protein that in humans is encoded by the TMOD3 gene.^[5][6]

TMOD3
Identifiers
Aliases	TMOD3, UTMOD, tropomodulin 3
External IDs	OMIM: 605112; MGI: 1355315; HomoloGene: 8727; GeneCards: TMOD3; OMA:TMOD3 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q21.2 Start 51,829,628 bp[1] End 51,947,295 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 D|9 42.3 cM Start 75,404,989 bp[2] End 75,466,939 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in amniotic fluid oral cavity buccal mucosa cell gums lower lobe of lung gingival epithelium epithelium of colon skin of hip Achilles tendon mucosa of sigmoid colon Top expressed in lactiferous gland Ileal epithelium corneal stroma left lung lobe sciatic nerve cardiac muscle tissue of left ventricle seminal vesicula right lung lobe blood genital tubercle More reference expression data BioGPS n/a
Gene ontology Molecular function actin binding cadherin binding involved in cell-cell adhesion tropomyosin binding Cellular component cytoplasm cytoskeleton striated muscle thin filament myofibril Biological process pointed-end actin filament capping positive regulation of mitotic cell cycle phase transition actin cytoskeleton organization erythrocyte development cell-cell adhesion muscle contraction actin filament organization myofibril assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29766 50875 Ensembl ENSG00000138594 ENSMUSG00000058587 UniProt Q9NYL9 Q9JHJ0 RefSeq (mRNA) NM_014547 NM_016963 NM_001357828 RefSeq (protein) NP_055362 NP_058659 NP_001344757 Location (UCSC) Chr 15: 51.83 – 51.95 Mb Chr 9: 75.4 – 75.47 Mb PubMed search [3] [4]
Wikidata
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Tropomodulin-3 (Tmod3) is a member of the tropomodulin family of actin-regulatory proteins that plays a key role in modulating the dynamics of the cytoskeleton by capping the pointed (minus) ends of actin filaments. Unlike some other tropomodulin isoforms, Tmod3 is widely expressed in non-muscle cells, where it contributes to essential cellular processes such as shape maintenance, motility, and adhesion. It regulates filament stability by preventing both polymerization and depolymerization at the pointed end, thus helping to define actin filament length and organization.^[7] In endothelial cells, Tmod3 has been shown to inhibit cell motility through its capping activity, highlighting its role as a negative regulator of actin-driven migration.^[8] Additionally, Tmod3 can bind not only to filamentous actin but also directly to actin monomers, suggesting a broader function in actin filament turnover and cytoskeletal remodeling.^[7]