Death receptor 4

Death receptor 4 (DR4), also known as TRAIL receptor 1 (TRAILR1) and tumor necrosis factor receptor superfamily member 10A (TNFRSF10A), is a cell surface receptor of the TNF-receptor superfamily that binds TRAIL and mediates apoptosis.^[5][6]

TNFRSF10A
Identifiers
Aliases	TNFRSF10A, APO2, CD261, DR4, TRAILR-1, TRAILR1, tumor necrosis factor receptor superfamily member 10a, TNF receptor superfamily member 10a
External IDs	OMIM: 603611; MGI: 1341090; HomoloGene: 129806; GeneCards: TNFRSF10A; OMA:TNFRSF10A - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p21.3 Start 23,190,452 bp[1] End 23,225,102 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D2 Start 70,004,921 bp[2] End 70,021,860 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell nipple pancreatic ductal cell tendon of biceps brachii pylorus lymph node superficial temporal artery epithelium of colon mucosa of pharynx nasal epithelium Top expressed in urethra female urethra male urethra genital tubercle morula endothelial cell of lymphatic vessel tail of embryo lens embryo embryo More reference expression data BioGPS n/a
Gene ontology Molecular function TRAIL binding transcription factor binding protease binding protein binding tumor necrosis factor-activated receptor activity death receptor activity signaling receptor activity Cellular component membrane plasma membrane integral component of plasma membrane cell surface intracellular anatomical structure integral component of membrane Biological process activation of NF-kappaB-inducing kinase activity TRAIL-activated apoptotic signaling pathway multicellular organism development cell surface receptor signaling pathway response to lipopolysaccharide cellular response to mechanical stimulus regulation of cell population proliferation immune response regulation of extrinsic apoptotic signaling pathway via death domain receptors inflammatory response activation of cysteine-type endopeptidase activity involved in apoptotic process extrinsic apoptotic signaling pathway via death domain receptors signal transduction negative regulation of extrinsic apoptotic signaling pathway via death domain receptors extrinsic apoptotic signaling pathway tumor necrosis factor-mediated signaling pathway apoptotic process leukocyte migration regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8797 21933 Ensembl ENSG00000104689 ENSMUSG00000022074 UniProt O00220 Q9QZM4 RefSeq (mRNA) NM_003844 NM_020275 RefSeq (protein) NP_003835 NP_064671 Location (UCSC) Chr 8: 23.19 – 23.23 Mb Chr 14: 70 – 70.02 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis.^[7]

Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.^[8]

Interactions

TNFRSF10A has been shown to interact with DAP3.^[9]