Decoy receptor 2

Decoy receptor 2 (DCR2), also known as TRAIL receptor 4 (TRAILR4) and tumor necrosis factor receptor superfamily member 10D (TNFRSF10D), is a human cell surface receptor of the TNF-receptor superfamily.^[3][4][5]

TNFRSF10D
Identifiers
Aliases	TNFRSF10D, CD264, DCR2, TRAIL-R4, TRAILR4, TRUNDD, tumor necrosis factor receptor superfamily member 10d, TNF receptor superfamily member 10d
External IDs	OMIM: 603614; HomoloGene: 136778; GeneCards: TNFRSF10D; OMA:TNFRSF10D - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p21.3 Start 23,135,588 bp[1] End 23,164,027 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue pancreatic epithelial cell stromal cell of endometrium pancreatic ductal cell islet of Langerhans mucosa of ileum right lobe of liver endothelial cell gastric mucosa monocyte n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transmembrane signaling receptor activity tumor necrosis factor-activated receptor activity TRAIL binding Cellular component integral component of membrane integral component of plasma membrane membrane plasma membrane cell surface Biological process multicellular organism development response to lipopolysaccharide inflammatory response negative regulation of apoptotic process regulation of cell population proliferation immune response signal transduction apoptotic process tumor necrosis factor-mediated signaling pathway regulation of apoptotic process leukocyte migration apoptotic signaling pathway negative regulation of cysteine-type endopeptidase activity involved in apoptotic process cell surface receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8793 n/a Ensembl ENSG00000173530 n/a UniProt Q9UBN6 n/a RefSeq (mRNA) NM_003840 n/a RefSeq (protein) NP_003831 n/a Location (UCSC) Chr 8: 23.14 – 23.16 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Function

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplasmic death domain.

This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis.^[5]