Decoy receptor 3

Decoy receptor 3 (Dcr3), also known as tumor necrosis factor receptor superfamily member 6B (TNFRSF6B), TR6 and M68, is a soluble protein of the tumor necrosis factor receptor superfamily which inhibits Fas ligand-induced apoptosis.^[3][4][5]

TNFRSF6B
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3K51, 3MHD, 3MI8, 4J6G, 4KGG, 4KGQ, 4MSV
Identifiers
Aliases	TNFRSF6B, DCR3, DJ583P15.1.1, M68, M68E, TR6, tumor necrosis factor receptor superfamily member 6b, TNF receptor superfamily member 6b
External IDs	OMIM: 603361; HomoloGene: 48242; GeneCards: TNFRSF6B; OMA:TNFRSF6B - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.33 Start 63,696,652 bp[1] End 63,698,684 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory zone of nasal mucosa spleen subcutaneous adipose tissue right lung upper lobe of left lung C1 segment right hemisphere of cerebellum appendix anterior pituitary Amygdala n/a More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding tumor necrosis factor-activated receptor activity signaling receptor activity Cellular component extracellular region integral component of plasma membrane extracellular space Biological process multicellular organism development apoptotic signaling pathway response to lipopolysaccharide inflammatory response tumor necrosis factor-mediated signaling pathway negative regulation of apoptotic process regulation of cell population proliferation immune response apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8771 n/a Ensembl ENSG00000243509 n/a UniProt O95407 n/a RefSeq (mRNA) NM_032945 NM_003823 n/a RefSeq (protein) NP_003814 n/a Location (UCSC) Chr 20: 63.7 – 63.7 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Discovery

Dcr3 was identified in 1998 by the search of genes with homology to the TNFR gene superfamily in expressed sequence tag (EST) database.

Structure

The open reading frame of TNFRSF6B encodes 300 amino acids with a 29-residue signal sequence and four tandem cystein-rich repeats. Two transcript variants encoding the same isoform, but differing in the 5' UTR, have been observed for this gene.^[5] Unlike most of the other members of TNFR superfamily, TNFRSF6 is a soluble protein which contains no transmembrane domain.

Function

This gene belongs to the tumor necrosis factor receptor superfamily. It acts as a decoy receptor that competes with death receptors for ligand binding. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death and T cell activation as well as to induce angiogenesis via neutralization of TL1A. Overexpression of this gene has been noted in various tumors e.g. gastrointestinal tract tumors, and it is located in a gene-rich cluster on chromosome 20, with other potentially tumor-related genes.^[5]

Interactions

TNFRSF6B has been shown to interact with:

• TNFSF14^[4][6][7]
• Fas ligand.^[3][4][7]