TP-003

TP-003 is an anxiolytic drug with a novel chemical structure, which is used in scientific research. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic.

TP-003

Identifiers
IUPAC name 5-fluoro-2-[4-fluoro-3-[8-fluoro-7-(2-hydroxypropan-2-yl)imidazo[1,2-a]pyridin-3-yl]phenyl]benzonitrile
CAS Number	628690-75-5 N
PubChem CID	9978724
ChemSpider	8154316 N
CompTox Dashboard (EPA)	DTXSID101108234
Chemical and physical data
Formula	C23H16F3N3O
Molar mass	407.396 g·mol−1
3D model (JSmol)	Interactive image
SMILES N#Cc4cc(F)ccc4-c1cc(ccc1F)-c2cnc3n2ccc(C(C)(O)C)c3F
InChI InChI=1S/C23H16F3N3O/c1-23(2,30)18-7-8-29-20(12-28-22(29)21(18)26)17-10-13(3-6-19(17)25)16-5-4-15(24)9-14(16)11-27/h3-10,12,30H,1-2H3 N Key:VLFITPUZJCLTFQ-UHFFFAOYSA-N N
NY (what is this?)  (verify)

TP-003 is a positive allosteric modulator at the benzodiazepine binding site of GABA_A receptors.^[1] It possesses relative selectivity for benzodiazepine sites on α3-containing GABA_A receptors, which are thought to contribute to the anxiolytic effects of benzodiazepines (in tandem with those containing α2 subunits).^[2] It has modest anticonvulsant activity although less than that of diazepam.^[3]

See also

• Imidazopyridine
• L-838,417
• Alpidem