Tropomyosin 3

Tropomyosin alpha-3 chain is a protein that in humans is encoded by the TPM3 gene.^[5][6]

TPM3
Identifiers
Aliases	TPM3, CAPM1, CFTD, HEL-189, HEL-S-82p, NEM1, OK/SW-cl.5, TM-5, TM3, TM30, TM30nm, TM5, TPMsk3, TRK, hscp30, Tropomyosin 3, TPM3nu
External IDs	OMIM: 191030; MGI: 1890149; HomoloGene: 81889; GeneCards: TPM3; OMA:TPM3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 154,155,304 bp[1] End 154,194,648 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F1 Start 89,979,956 bp[2] End 90,008,209 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh Skeletal muscle tissue of rectus abdominis thoracic diaphragm biceps brachii gastrocnemius muscle Skeletal muscle tissue of biceps brachii glutes vastus lateralis muscle triceps brachii muscle monocyte Top expressed in soleus muscle tail of embryo genital tubercle granulocyte ankle plantaris muscle intercostal muscle yolk sac extraocular muscle thoracic diaphragm More reference expression data BioGPS n/a
Gene ontology Molecular function actin binding protein binding structural constituent of muscle actin filament binding molecular function Cellular component cytoplasm muscle thin filament tropomyosin extracellular exosome cytoskeleton stress fiber cytosol actin filament actin cytoskeleton Biological process muscle filament sliding muscle contraction actin filament organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7170 59069 Ensembl ENSG00000143549 ENSMUSG00000027940 UniProt P06753 P21107 RefSeq (mRNA) NM_001043351 NM_001043352 NM_001043353 NM_001278188 NM_001278189 NM_001278190 NM_001278191 NM_152263 NM_153649 NM_001349679 NM_001364679 NM_001364680 NM_001364681 NM_001364682 NM_001364683 NM_001253738 NM_001253740 NM_001271764 NM_001293748 NM_001293749 NM_022314 NM_001357581 RefSeq (protein) NP_001036816 NP_001036817 NP_001036818 NP_001265117 NP_001265118 NP_001265119 NP_001265120 NP_689476 NP_705935 NP_001336608 NP_001351608 NP_001351609 NP_001351610 NP_001351611 NP_001351612 NP_001240667 NP_001240669 NP_001258693 NP_001280677 NP_001280678 NP_071709 NP_001344510 Location (UCSC) Chr 1: 154.16 – 154.19 Mb Chr 3: 89.98 – 90.01 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene.^[6]