TRNA (adenine58-N1)-methyltransferase

TRNA (adenine⁵⁸-N¹)-methyltransferase (EC 2.1.1.220, tRNA m1A58 methyltransferase, tRNA (m1A58) methyltransferase, TrmI, tRNA (m1A58) Mtase, Rv2118cp, Gcd10p-Gcd14p, Trm61p-Trm6p) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (adenine⁵⁸-N¹)-methyltransferase.^[1][2][3] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + adenine⁵⁸ in tRNA ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + N¹-methyladenine⁵⁸ in tRNA

TRNA (adenine58-N1)-methyltransferase
Identifiers
EC no.	2.1.1.220
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

The enzyme specifically methylates adenine⁵⁸ in tRNA.