TRNA (cytidine56-2'-O)-methyltransferase

tRNA (cytidine56-2'-O)-methyltransferase (EC 2.1.1.206, aTrm⁵⁶, tRNA ribose 2'-O-methyltransferase aTrm⁵⁶, PAB1040 (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (cytidine56-2'-O)-methyltransferase.^[1][2] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + cytidine⁵⁶ in tRNA ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + 2'-O-methylcytidine⁵⁶ in tRNA

tRNA (cytidine56-2'-O)-methyltransferase
Identifiers
EC no.	2.1.1.206
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

The archaeal enzyme specifically catalyses the S-adenosyl-L-methionine dependent 2'-O-ribose methylation of cytidine at position 56 in tRNA transcripts.