TRNA (guanine26-N2)-dimethyltransferase

TRNA (guanine²⁶-N²)-dimethyltransferase (EC 2.1.1.216, Trm1p, TRM1, tRNA (m22G26)dimethyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine²⁶-N²)-dimethyltransferase.^[1][2][3][4] This enzyme catalyses the following chemical reaction

2 S-adenosyl-L-methionine + guanine²⁶ in tRNA ${\displaystyle \rightleftharpoons }$ 2 S-adenosyl-L-homocysteine + N²-dimethylguanine26 in tRNA

TRNA (guanine26-N2)-dimethyltransferase
Identifiers
EC no.	2.1.1.216
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
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The enzyme dissociates from its tRNA substrate between the two consecutive methylation reactions.