Tandamine

Tandamine is a selective norepinephrine reuptake inhibitor with a tricyclic structure.^[1][2][3] It was developed in the 1970s as an antidepressant but was never commercialized.^[1][2][3] Tandamine is analogous to pirandamine, which, instead, acts as a selective serotonin reuptake inhibitor (SSRI).^[4][5]

Tandamine

Clinical data
ATC code	none
Identifiers
IUPAC name 2-(9-ethyl-1-methyl-3,4-dihydrothiopyrano[3,4-b]indol-1-yl)-N,N-dimethylethanamine
CAS Number	42408-80-0 Y HCl: 58167-78-5 Y
PubChem CID	39187
ChemSpider	35851
UNII	6L5FH5A43E HCl: 7516K9UGUG Y
CompTox Dashboard (EPA)	DTXSID70866094
Chemical and physical data
Formula	C18H26N2S
Molar mass	302.48 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCn3c1ccccc1c2CCSC(C)(CCN(C)C)c23
InChI InChI=1S/C18H26N2S/c1-5-20-16-9-7-6-8-14(16)15-10-13-21-18(2,17(15)20)11-12-19(3)4/h6-9H,5,10-13H2,1-4H3 Key:BRPOADLGOFPKKJ-UHFFFAOYSA-N
(verify)

The exact identical same structure, although this time changing the thioether to a methylene group revealed a strongest compound of the series called AY 24614.^[6]

See also

• Pirandamine