Taurochenodeoxycholate 6α-hydroxylase

Taurochenodeoxycholate 6alpha-hydroxylase (EC 1.14.13.97, CYP3A4, CYP4A21, taurochenodeoxycholate 6alpha-monooxygenase) is an enzyme with systematic name taurochenodeoxycholate,NADPH:oxygen oxidoreductase (6alpha-hydroxylating).^{[1][2][3][4][5][6]} This enzyme catalyses the following chemical reaction

(1) taurochenodeoxycholate + NADPH + H⁺ + O₂ ${\displaystyle \rightleftharpoons }$ taurohyocholate + NADP⁺ + H₂O

(2) lithocholate + NADPH + H⁺ + O₂ ${\displaystyle \rightleftharpoons }$ hyodeoxycholate + NADP⁺ + H₂O

Taurochenodeoxycholate 6alpha-hydroxylase
Identifiers
EC no.	1.14.13.97
CAS no.	105669-85-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Taurochenodeoxycholate 6α-hydroxylase is a heme-thiolate protein (P-450).

See also

• CYP3A4