Tenidap

Tenidap was a COX/5-LOX inhibitor and cytokine-modulating anti-inflammatory drug candidate^[1] that was under development by Pfizer as a promising potential treatment for rheumatoid arthritis,^[2] but Pfizer halted development after marketing approval was rejected by the FDA in 1996^[3] due to liver and kidney toxicity, which was attributed to metabolites of the drug with a thiophene moiety that caused oxidative damage.^[4]

Tenidap

Clinical data
ATC code	M01AX23 (WHO)
Identifiers
IUPAC name 5-chloro-2-hydroxy-3-(2-thienylcarbonyl)-1H-indole-1-carboxamide
CAS Number	120210-48-2 Y
PubChem CID	60712
ChemSpider	54717 N
UNII	9K7CJ74ONH
KEGG	D06072 Y
ChEMBL	ChEMBL1097558 N
CompTox Dashboard (EPA)	DTXSID9046104
Chemical and physical data
Formula	C14H9ClN2O3S
Molar mass	320.75 g·mol−1
3D model (JSmol)	Interactive image
SMILES c1cc(sc1)C(=O)c2c3cc(ccc3n(c2O)C(=O)N)Cl
InChI InChI=1S/C14H9ClN2O3S/c15-7-3-4-9-8(6-7)11(13(19)17(9)14(16)20)12(18)10-2-1-5-21-10/h1-6,19H,(H2,16,20) N Key:IZSFDUMVCVVWKW-UHFFFAOYSA-N N
NY (what is this?)  (verify)