Testosterone 17b-dehydrogenase (NADP+)

Testosterone 17beta-dehydrogenase (NADP⁺) (EC 1.1.1.64, 17-ketoreductase, NADP-dependent testosterone-17beta-oxidoreductase, testosterone 17beta-dehydrogenase (NADP)) is an enzyme with systematic name 17beta-hydroxysteroid:NADP⁺ 17-oxidoreductase.^[1][2][3] This enzyme catalyses the following chemical reaction

testosterone + NADP⁺ ${\displaystyle \rightleftharpoons }$ androstenedione + NADPH + H⁺

Testosterone 17beta-dehydrogenase (NADP+)
Identifiers
EC no.	1.1.1.64
CAS no.	9028-63-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
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Also oxidizes 3-hydroxyhexobarbital to 3-oxohexobarbital.