Thelephoric acid

Thelephoric acid is a terphenylquinone pigment that is found in several fungi, such as Omphalotus subilludens^[1] and Polyozellus multiplex.^[2] Thelephoric acid has been shown to inhibit prolyl endopeptidase, an enzyme that has a role in processing proteins (specifically, amyloid precursor protein) in Alzheimer's disease. Chemicals that inhibit prolyl endopeptidase have attracted research interest due to their potential therapeutic effects.^[3][4] It is derived from atromentin, and its precursor can be from cyclovariegatin. Fragmentation patterns have suggested that polymers of thelephoric acid exists.

Thelephoric acid

Names
Preferred IUPAC name 2,3,8,9-Tetrahydroxybenzo[1,2-b:4,5-b′]bis([1]benzofuran)-6,12-dione
Identifiers
CAS Number	479-64-1 N
3D model (JSmol)	Interactive image
ChEBI	CHEBI:144238
ChEMBL	ChEMBL3236668
ChemSpider	30776833
PubChem CID	135464206
CompTox Dashboard (EPA)	DTXSID201028792
InChI InChI=1S/C18H8O8/c19-7-1-5-11(3-9(7)21)25-17-13(5)15(23)18-14(16(17)24)6-2-8(20)10(22)4-12(6)26-18/h1-4,19-22H Key: PDICCECAPKBDBB-UHFFFAOYSA-N InChI=1/C18H8O8/c19-7-1-5-11(3-9(7)21)25-17-13(5)15(23)18-14(16(17)24)6-2-8(20)10(22)4-12(6)26-18/h1-4,19-22H Key: PDICCECAPKBDBB-UHFFFAOYAC
SMILES c1c2c(cc(c1O)O)oc3c2C(=O)c4c(c5cc(c(cc5o4)O)O)C3=O
Properties
Chemical formula	C18H8O8
Molar mass	352.254 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references