Thio-THIP

Thio-THIP, also known as 4,5,6,7-tetrahydroisothiazolo[5,4-c]pyridin-3-ol, is a low-potency GABA_A receptor very weak partial agonist or antagonist related to gaboxadol (THIP).^[1][2][3] It is also a weak GABA_A-ρ receptor antagonist^[4][5] and a weak GABA reuptake inhibitor.^[2] The drug has three orders of magnitude lower potency as a GABA_A receptor modulator than gaboxadol.^[6][7] This is unlike the case of muscimol and thiomuscimol, which are almost equipotent.^[8] Like gaboxadol, thio-THIP is a zwitterion.^[1][8] It may cross the blood–brain barrier similarly to gaboxadol.^[8] Thio-THIP was developed and described by Povl Krogsgaard-Larsen and colleagues by 1981.^[6][9][7]

Thio-THIP

Clinical data
Other names	4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol; Thiogaboxadol
Drug class	GABAA receptor weak partial agonist or antagonist; GABAA-ρ receptor antagonist; GABA reuptake inhibitor
ATC code	None
Identifiers
IUPAC name 4,5,6,7-tetrahydro-[1,2]thiazolo[5,4-c]pyridin-3-one
CAS Number	97164-95-9
PubChem CID	656720
ChemSpider	571058
KEGG	C13711
ChEBI	CHEBI:35010
ChEMBL	ChEMBL170539
Chemical and physical data
Formula	C6H8N2OS
Molar mass	156.20 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1CNCC2=C1C(=O)NS2
InChI InChI=1S/C6H8N2OS/c9-6-4-1-2-7-3-5(4)10-8-6/h7H,1-3H2,(H,8,9) Key:DZYJTJJQGHXSFN-UHFFFAOYSA-N

See also

• Aza-THIP
• Iso-THIP
• THAZ
• THPO
• 4-PIOL
• Thio-4-PIOL