Thioperamide

Thioperamide is a potent HRH₄ antagonist and selective HRH₃ antagonist capable of crossing the blood–brain barrier.^[1] It was used by Jean-Charles Schwartz in his early experiments regarding the H₃ receptor.^[2] Thioperamide was found to be an antagonist of histamine autoreceptors, which negatively regulate the release of histamine. The drug enhances the activity of histaminergic neurons by blocking autoreceptors, leading to greater release of histamine.

Thioperamide

Clinical data
ATC code	none
Identifiers
IUPAC name N-Cyclohexyl-4-(1H-imidazol-4-yl)piperidine-1-carbothioamide
CAS Number	106243-16-7 N
PubChem CID	3035905
IUPHAR/BPS	1267
ChemSpider	2300031 Y
UNII	II4319BWUI
ChEMBL	ChEMBL260374 Y
CompTox Dashboard (EPA)	DTXSID50147555
Chemical and physical data
Formula	C15H24N4S
Molar mass	292.45 g·mol−1
3D model (JSmol)	Interactive image
SMILES S=C(NC1CCCCC1)N3CCC(c2cnc[nH]2)CC3
InChI InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20) Y Key:QKDDJDBFONZGBW-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Its action on H₃ receptors is thought to promote wakefulness and improve memory consolidation.

See also

• H₃ receptor antagonist