Thymopentin

Thymopentin is a thymic polypeptide derivative which interacts with T cells and acts as an immunostimulant.^[1][2][3][4] As such, it was used in several clinical studies in the early years of the AIDS pandemic (from 1983 to 1985). Thymopentin helped to improve immunological condition in some patients for a brief time under specific treatments.^[5][6][7] It has also been investigated more recently for applications in the treatment of rheumatoid arthritis,^[8] and lung cancer.^[9]

Thymopentin

Clinical data
Other names	L-arginyl-L-lysyl-L-α-aspartyl-L-valyl-L-tyrosine
ATC code	L03AX09 (WHO)
Identifiers
IUPAC name (3S)-3-[[(2S)-6-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-4-[[(2S)-1-[[(2S)-1-hydroxy-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid
CAS Number	69558-55-0 Y
PubChem CID	451417
ChemSpider	397640 Y
UNII	O3Y80ZF13F
KEGG	D06117 Y
ChEMBL	ChEMBL156025 Y
NIAID ChemDB	000127
CompTox Dashboard (EPA)	DTXSID9046609
ECHA InfoCard	100.242.320
Chemical and physical data
Formula	C30H49N9O9
Molar mass	679.776 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C(N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1ccc(O)cc1)C(C)C)CC(=O)O)CCCCN)[C@@H](N)CCC/N=C(\N)N
InChI InChI=1S/C30H49N9O9/c1-16(2)24(28(46)38-22(29(47)48)14-17-8-10-18(40)11-9-17)39-27(45)21(15-23(41)42)37-26(44)20(7-3-4-12-31)36-25(43)19(32)6-5-13-35-30(33)34/h8-11,16,19-22,24,40H,3-7,12-15,31-32H2,1-2H3,(H,36,43)(H,37,44)(H,38,46)(H,39,45)(H,41,42)(H,47,48)(H4,33,34,35)/t19-,20-,21-,22-,24-/m0/s1 Y Key:PSWFFKRAVBDQEG-YGQNSOCVSA-N Y
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See also

• Thymopoietin