Thymopentin

Thymopentin is an immunostimulant. As such, it has been used in several clinical studies in the early years of the AIDS pandemic (from 1983 to 1985). Thymopentin helped to improve immunological condition in several patients for a brief time under specific treatments.^[1][2][3]

Thymopentin

Clinical data
Other names	L-arginyl-L-lysyl-L-α-aspartyl-L-valyl-L-tyrosine
ATC code	L03AX09 (WHO)
Identifiers
IUPAC name (3S)-3-[[(2S)-6-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-4-[[(2S)-1-[[(2S)-1-hydroxy-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid
CAS Number	69558-55-0 Y
PubChem CID	451417
ChemSpider	397640 Y
UNII	O3Y80ZF13F
KEGG	D06117 Y
ChEMBL	ChEMBL156025 Y
NIAID ChemDB	000127
CompTox Dashboard (EPA)	DTXSID9046609
ECHA InfoCard	100.242.320
Chemical and physical data
Formula	C30H49N9O9
Molar mass	679.776 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C(N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1ccc(O)cc1)C(C)C)CC(=O)O)CCCCN)[C@@H](N)CCC/N=C(\N)N
InChI InChI=1S/C30H49N9O9/c1-16(2)24(28(46)38-22(29(47)48)14-17-8-10-18(40)11-9-17)39-27(45)21(15-23(41)42)37-26(44)20(7-3-4-12-31)36-25(43)19(32)6-5-13-35-30(33)34/h8-11,16,19-22,24,40H,3-7,12-15,31-32H2,1-2H3,(H,36,43)(H,37,44)(H,38,46)(H,39,45)(H,41,42)(H,47,48)(H4,33,34,35)/t19-,20-,21-,22-,24-/m0/s1 Y Key:PSWFFKRAVBDQEG-YGQNSOCVSA-N Y
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It interacts with T cells.^[4]

It is a thymic polypeptide.^[5]