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Tissue-selective estrogen complex

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A tissue-selective estrogen complex (TSEC) is a combination of an estrogen, such as estradiol or conjugated estrogens, and a selective estrogen receptor modulator (SERM), such as tamoxifen, raloxifene, or bazedoxifene.[1] It is thought to have different tissue pattern of estrogenic and antiestrogenic effects than that of either the estrogen or the SERM alone.[1] An example of a clinically used TSEC is conjugated estrogens/bazedoxifene (brand name Duavee).[2]

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