Tissue-selective estrogen complex

A tissue-selective estrogen complex (TSEC) is a combination of an estrogen, such as estradiol or conjugated estrogens, and a selective estrogen receptor modulator (SERM), such as tamoxifen, raloxifene, or bazedoxifene.^[1] It is thought to have different tissue pattern of estrogenic and antiestrogenic effects than that of either the estrogen or the SERM alone.^[1] An example of a clinically used TSEC is conjugated estrogens/bazedoxifene (brand name Duavee).^[2]