Toker cell

A Toker cell is an epithelial cell with clear cytoplasm in the nipple of some women.^[1] Toker cells are believed to develop from sebaceous glands.^[1] They are cytokeratin 7 (CK7) positive, in contrast to squamous epithelium.^[1] Rarely, they can be numerous and atypical, and difficult to distinguish from malignant cells of Paget's disease of the breast.^[2] In such cases, immunohistochemistry using CD138 and p53 can be used for distinction, both being negative in Toker cells and positive in Paget's disease.^[2]