Toltrazuril

Toltrazuril is an antiparasitic medication used primarily to treat coccidiosis in animals. Coccidiosis is a parasitic disease caused by coccidia, which are microscopic, spore-forming, single-celled obligate intracellular parasites belonging to the apicomplexan class Conoidasida.^[1][2][3]

Toltrazuril

Clinical data
Trade names	Baycox, Tolcox
AHFS/Drugs.com	International Drug Names
ATCvet code	QP51BC01 (WHO) QP51BC51 (WHO)
Legal status
Legal status	CA: ℞-only
Identifiers
IUPAC name 1-methyl-3-[3-methyl-4-[4-(trifluoromethylthio)phenoxy]phenyl]-1,3,5-triazinane-2,4,6-trione
CAS Number	69004-03-1 Y
PubChem CID	68591
ChemSpider	61859 N
UNII	QVZ3IAR3JS
KEGG	D06187 Y
ChEMBL	ChEMBL2104931 N
CompTox Dashboard (EPA)	DTXSID90219063
ECHA InfoCard	100.132.547
Chemical and physical data
Formula	C18H14F3N3O4S
Molar mass	425.38 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC1=C(C=CC(=C1)N2C(=O)NC(=O)N(C2=O)C)OC3=CC=C(C=C3)SC(F)(F)F
InChI InChI=1S/C18H14F3N3O4S/c1-10-9-11(24-16(26)22-15(25)23(2)17(24)27)3-8-14(10)28-12-4-6-13(7-5-12)29-18(19,20)21/h3-9H,1-2H3,(H,22,25,26) N Key:OCINXEZVIIVXFU-UHFFFAOYSA-N N
NY (what is this?)  (verify)

Mechanism of action

Toltrazuril works by interfering with the protozoa's ability to reproduce. It disrupts the division of the protozoal nucleus and damages the cell membrane of the parasites. This action results in the destruction of the coccidia at all stages of their life cycle.^[4]

Use in veterinary medicine

Toltrazuril is widely used in veterinary medicine to treat coccidiosis in various animals, including poultry, pigs, cattle, sheep, and companion animals like dogs and cats. It is often administered as a single dose or in a series of doses depending on the severity of the infection and the species being treated.^[5][6]