Torin-1

Torin_1 is a drug which was one of the first non-rapalog derived inhibitors of the mechanistic target of rapamycin (mTOR) subtypes mTORC1 and mTORC2.^[1][2][3] In animal studies it has anti-inflammatory,^[4][5] anti-cancer,^[6][7] and anti-aging properties,^{[8][9][10][11]} and shows activity against neuropathic pain.^[12][13][14]

Torin_1

Identifiers
IUPAC name 1-[4-(4-propanoylpiperazin-1-yl)-3-(trifluoromethyl)phenyl]-9-quinolin-3-ylbenzo[h][1,6]naphthyridin-2-one
CAS Number	1222998-36-8
PubChem CID	49836027
ChemSpider	26232175
UNII	K9HTV88VQZ
ChEBI	CHEBI:84327
ChEMBL	ChEMBL1256459
CompTox Dashboard (EPA)	DTXSID40678621
Chemical and physical data
Formula	C35H28F3N5O2
Molar mass	607.637 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCC(=O)N1CCN(CC1)C2=C(C=C(C=C2)N3C(=O)C=CC4=CN=C5C=CC(=CC5=C43)C6=CC7=CC=CC=C7N=C6)C(F)(F)F
InChI InChI=1S/C35H28F3N5O2/c1-2-32(44)42-15-13-41(14-16-42)31-11-9-26(19-28(31)35(36,37)38)43-33(45)12-8-24-20-40-30-10-7-22(18-27(30)34(24)43)25-17-23-5-3-4-6-29(23)39-21-25/h3-12,17-21H,2,13-16H2,1H3 Key:AKCRNFFTGXBONI-UHFFFAOYSA-N