Trans-activation response element
RNA family From Wikipedia, the free encyclopedia
The HIV trans-activation response (TAR) element is an RNA element which is known to be required for the trans-activation of the viral promoter and for virus replication. The TAR hairpin is a dynamic structure[1] that acts as a binding site for the Tat protein, and this interaction stimulates the activity of the long terminal repeat promoter.[2]
Trans-activation response element (TAR) | |
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![]() Predicted secondary structure and sequence conservation of mir-TAR | |
Identifiers | |
Symbol | mir-TAR |
Alt. Symbols | TAR |
Rfam | RF00250 |
Other data | |
RNA type | Gene; miRNA |
Domain(s) | Viruses |
GO | GO:0035068 GO:0035195 |
SO | SO:0000233 SO:0001244 |
PDB structures | PDBe |
Further analysis has shown that TAR is a pre-microRNA that produces mature microRNAs from both strands of the TAR stem-loop.[3] These miRNAs are thought to prevent infected cells from undergoing apoptosis by downregulating the genes ERCC1, IER3,[4] CDK9, and Bim.[5]
Human polyomavirus 2 (JC virus) contains a TAR-homologous sequence in its late promoter[6] that is responsive to HIV-1 derived Tat.[7][8]
References
External links
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