BCL2L11

Bcl-2-like protein 11, commonly called BIM (Bcl-2 Interacting Mediator of cell death), is a protein that in humans is encoded by the BCL2L11 gene.^[5][6]

BCL2L11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1F95, 2K7W, 2NL9, 2V6Q, 2VM6, 2WH6, 2YQ6, 2YQ7, 3D7V, 3FDL, 3IO8, 3IO9, 3KJ0, 3KJ1, 3KJ2, 4A1U, 4A1W, 4B4S, 4D2M, 4QVF, 4UF3, 4YJ4, 4ZIF, 4ZIH, 5AGW, 5AGX, 5C3G
Identifiers
Aliases	BCL2L11, BAM, BIM, BOD, BCL2 like 11
External IDs	OMIM: 603827; MGI: 1197519; HomoloGene: 7643; GeneCards: BCL2L11; OMA:BCL2L11 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q13 Start 111,119,378 bp[1] End 111,168,445 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 F1 Start 127,967,958 bp[2] End 128,004,467 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm palpebral conjunctiva epithelium of nasopharynx mucosa of paranasal sinus superficial temporal artery gingival epithelium monocyte mucosa of colon mucosa of sigmoid colon jejunal mucosa Top expressed in transitional epithelium of urinary bladder vestibular membrane of cochlear duct ciliary body internal carotid artery retinal pigment epithelium utricle Rostral migratory stream external carotid artery blood endothelial cell of lymphatic vessel More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding microtubule binding dynein complex binding protein heterodimerization activity protein kinase binding Cellular component cytoplasm cytosol membrane intracellular membrane-bounded organelle BIM-BCL-2 complex mitochondrial outer membrane BIM-BCL-xl complex cytoplasmic dynein complex mitochondrion microtubule endomembrane system extrinsic component of membrane Bcl-2 family protein complex Biological process leukocyte homeostasis regulation of apoptotic process positive regulation of protein homooligomerization male gonad development positive regulation of cell death positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway B cell apoptotic process kidney development thymus development lymphocyte homeostasis positive regulation of apoptotic process by virus myeloid cell homeostasis post-embryonic animal organ morphogenesis ear development in utero embryonic development B cell homeostasis spleen development thymocyte apoptotic process post-embryonic development response to endoplasmic reticulum stress mammary gland development T cell homeostasis odontogenesis of dentin-containing tooth positive regulation of IRE1-mediated unfolded protein response positive regulation of cysteine-type endopeptidase activity involved in apoptotic process tube formation brain development positive regulation of neuron apoptotic process positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway positive regulation of cell cycle positive regulation of mitochondrial membrane permeability involved in apoptotic process meiosis I spermatogenesis intrinsic apoptotic signaling pathway in response to DNA damage extrinsic apoptotic signaling pathway in absence of ligand positive regulation of apoptotic process positive regulation of fibroblast apoptotic process developmental pigmentation positive regulation of release of cytochrome c from mitochondria regulation of developmental pigmentation cell-matrix adhesion regulation of organ growth activation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of intrinsic apoptotic signaling pathway apoptotic process involved in embryonic digit morphogenesis apoptotic process protein insertion into mitochondrial membrane involved in apoptotic signaling pathway positive regulation of autophagy in response to ER overload cellular response to glucocorticoid stimulus cellular response to estradiol stimulus cellular response to amyloid-beta Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10018 12125 Ensembl ENSG00000153094 ENSMUSG00000027381 UniProt O43521 O54918 RefSeq (mRNA) NM_001204106 NM_001204107 NM_001204108 NM_001204109 NM_001204110 NM_001204111 NM_001204112 NM_001204113 NM_006538 NM_138621 NM_138622 NM_138623 NM_138624 NM_138625 NM_138626 NM_138627 NM_207002 NM_207003 NM_001284410 NM_001291016 NM_009754 NM_207680 NM_207681 RefSeq (protein) NP_001191035 NP_001191036 NP_001191037 NP_001191038 NP_001191039 NP_001191040 NP_001191041 NP_001191042 NP_006529 NP_619527 NP_619528 NP_619529 NP_619530 NP_619531 NP_619532 NP_619533 NP_996885 NP_996886 NP_001271339 NP_001277945 NP_033884 NP_997563 NP_997564 NP_001392986 NP_001392987 NP_001392988 NP_001392989 NP_001392990 Location (UCSC) Chr 2: 111.12 – 111.17 Mb Chr 2: 127.97 – 128 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1 (FoxO3a), which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.^[7]

Regulation of Bim

Bim expression and activity are regulated at the transcriptional, translational and post-translational levels; coordinated expression and activity of Bim shape immune responses, and ensure tissue integrity. Cancer cells develop mechanisms that suppress Bim expression, which allows for tumor progression and metastasis.^[8]

Interactions

BCL2L11 has been shown to interact with:

• BCL2-like 1,^{[5][6][9][10]}
• BCL2L2,^[5][6]
• Bcl-2,^[5][6][9]
• DYNLL1,^[11][12] and
• MCL1.^{[5][9][13][14]}

See also

• Bcl-2