Transformer (gene)

Not to be confused with Transformer proteins.

Transformer (tra) is a family of genes which regulate sex determination in insects such as flies.^[1][2] Among its effects, it (P11596) regulates differences between males and females in Drosophila fruit flies.^[3]

Alternative splicing of the Drosophila Transformer gene product.

Female-specific protein transformer
Identifiers
Symbol	Tra
Pfam	PF06495
InterPro	IPR010519
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Transformer
Identifiers
Organism	Drosophila melanogaster
Symbol	tra
Entrez	39849
RefSeq (mRNA)	NM_079390.3
RefSeq (Prot)	NP_524114.1
UniProt	P11596
Other data
Chromosome	3L: 16.59 - 16.59 Mb
Search for Structures Swiss-model Domains InterPro

Transformer 2
Identifiers
Organism	Drosophila melanogaster
Symbol	tra2
Entrez	36619
RefSeq (mRNA)	NM_057416.3
RefSeq (Prot)	NP_476764.1
UniProt	P19018
Other data
Chromosome	2R: 14.6 - 14.6 Mb
Search for Structures Swiss-model Domains InterPro

The tra-2 gene (P19018) is needed for sexual differentiation in female fruit flies, and for spermatogenesis in the males. It is not in the same protein family as tra, but instead works together with it in the splicing enhancer complex.^[4][5]