Transperineal biopsy

A transperineal prostate biopsy is a medical procedure in which a sample of tissue is taken from the prostate gland for diagnostic purposes by going through the perineum (area in between the anus and the scrotum).

Prostate tissue biopsy
48-hour post transperineal biopsy
Purpose	Obtain a tissue sample from the prostate gland for diagnostic purposes via the perineum.
Test of	Prostate gland

Procedure

The prostate can be accessed through the perineum, between the scrotum and anus. The patient may be given a mild sedative and the area is numbed with a local anaesthetic. The tissue samples are sent to a laboratory for analysis.

Types of prostate biopsies

Prostate biopsies can also be performed using the transrectal or transurethral approach.

Transrectal biopsies involve inserting a needle through the rectum to obtain tissue, but they may not accurately sample the entire prostate, increasing the risk of missed diagnoses, and they have a higher risk of infection due to the insertion through the rectum. In addition, the rectum can obstruct the view of the prostate, making it more difficult to obtain accurate tissue samples.

Transperineal biopsies have greater accuracy, a lower risk of infection, and better visualization of the prostate. Because of the lower risk of infection, the biopsy can be done with few antibiotics.^[1] They were historically less common because they were more difficult and time-consuming to perform, requiring a surgical room, a medical team, and full anesthesia. Technological advancements have made transperineal biopsies easier to perform.